Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 80,500 |
5 mg | 在庫あり | ¥ 223,000 |
25 mg | 在庫あり | ¥ 335,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 574,000 |
説明 | PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes. |
ターゲット&IC50 | PTP1B:120 nM, TCPTP:120 nM |
In vivo | In NDL2 Ptpn1 transgenic mice, oral administration of PTP1B-IN-3 (compound 3g) at a dose of 30 mg/kg for 21 days significantly delayed the onset of tumor development in NDL2 Ptpn1+/+ mice, extending the median tumor-free days (T50) from 28 days to 75 days [2].In diet-induced obese (DIO) mice, PTP1B-IN-3 (compound 3g) exhibits good oral bioavailability (F of 24%), slow clearance (CL of 0.71 mL/kg/min), and excellent elimination half-life (t1/2 of 6 hours)[2]. |
分子量 | 362.06 |
分子式 | C12H7BrF2NO3P |
CAS No. | 809272-64-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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PTP1B-IN-3 809272-64-8 Metabolism Phosphatase PTP-1B-IN-3 PTP1BIN3 PTP1B IN 3 Inhibitor inhibitor inhibit