Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand. It also can inhibit FANCJ and DinG helicases (IC50s: 65±6 and 50±10 nM, respectively).
ターゲット&IC50 | DinG helicases (G4 substrate):50±10 nM, FANCJ helicase (G4 substrate):65±6 nM |
In vitro | The CEB25-L111(T) array remains stable in wild-type (WT) cells but exhibits instability when treated with Phen-DC3 Trifluoromethanesulfonate or upon PIF1 gene deletion. Similarly, the CEB1-WT array, while generally stable, shows frequent rearrangements after exposure to 10 μM Phen-DC3 Trifluoromethanesulfonate in WT cells. The c-Myc allele is significantly destabilized following Phen-DC3 Trifluoromethanesulfonate treatment or PIF1 deletion, revealing high susceptibility to destabilization under these conditions. Meanwhile, the CEB1-loop CEB25 allele maintains full stability in both scenarios involving PIF1 treatment or in WT cells, indicating a distinct response to these genetic interventions. |
別名 | Phen-DC3 Triflate |
分子量 | 848.75 |
分子式 | C36H26F6N6O8S2 |
CAS No. | 929895-45-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 34 mg/mL (40.06 mM)
You can also refer to dose conversion for different animals. 詳細
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Phen-DC3 Trifluoromethanesulfonate 929895-45-4 Others PhenDC3 Trifluoromethanesulfonate Phen-DC-3 Trifluoromethanesulfonate Phen-DC3 Triflate Phen DC3 Trifluoromethanesulfonate Inhibitor inhibitor inhibit