Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle recycling.
説明 | Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle recycling. |
In vitro | Pitstop2 potently and specifically reduced HIV-1 infectivity by >90% in HeLa cells. Preincubation of HeLa cells with Pitstop2 (Pitstops 2) leads to a dose-dependent inhibition of Tf uptake with an IC50 value (12-5 μM). Application of 30 μM Pitstop2 completely blocked Tf endocytosis. Pitstop2-induced block of Tf endocytosis in HeLa cells was completely reversed within 1-3 hr of drug washout. In U2OS cells, the IC50 for Tf uptake is 9.7 μM. Pitstop 2 also causes a potent inhibition of EGF uptake[1]. |
分子量 | 473.36 |
分子式 | C20H13BrN2O3S2 |
CAS No. | 1419320-73-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.88 mg/mL (14.52 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Pitstop 2 1419320-73-2 Apoptosis cancer Pitstop2 Pitstop-2 endocytosis clathrin-mediated inhibit CME Inhibitor clathrin inhibitor