Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate shows antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection.
説明 | Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate shows antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. |
ターゲット&IC50 | HSV1-2:0.02 μM |
In vivo | Pritelivir mesylate is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex. Pritelivir mesylate has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis. Pritelivir mesylate (0.03-45 mg/kg) significantly increases survival. Pritelivir mesylate (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Combination therapies of Pritelivir mesylate at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS [2][3]. |
別名 | BAY 57-1293 mesylate, AIC316 mesylate |
分子量 | 498.6 |
分子式 | C19H22N4O6S3 |
CAS No. | 1428333-96-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Pritelivir mesylate 1428333-96-3 Others Pritelivir Mesylate AIC 316 Mesylate BAY 57-1293 mesylate AIC-316 Mesylate AIC316 Mesylate BAY 57-1293 Mesylate AIC316 mesylate Inhibitor inhibitor inhibit