Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate hydrate shows antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection.
説明 | Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate hydrate shows antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. |
ターゲット&IC50 | HSV1-2:0.02 μM |
In vivo | Pritelivir mesylate hydrate is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex. Pritelivir mesylate hydrate has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis. Pritelivir mesylate hydrate (0.03-45 mg/kg) significantly increases survival. Pritelivir mesylate hydrate (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Combination therapies of Pritelivir mesylate hydrate at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS [2][3]. |
別名 | BAY 57-1293 mesylate hydrate, AIC316 mesylate hydrate |
分子量 | 516.61 |
分子式 | C19H24N4O7S3 |
CAS No. | 1428321-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Pritelivir mesylate hydrate 1428321-10-1 Others BAY 57-1293 mesylate hydrate AIC316 mesylate hydrate AIC316 mesylate Hydrate Pritelivir mesylate Hydrate BAY 57-1293 mesylate Hydrate Inhibitor inhibitor inhibit