Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].
説明 | Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1]. |
In vitro | BTK-CRBN PROTACs function as stoichiometric degraders, leading to the degradation of the BTK protein. This process occurs through the recruitment of the cereblon E3 ligases family[1]. |
分子量 | 128.13 |
分子式 | C6H8O3 |
CAS No. | 55683-37-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Propargyl-PEG1-acid 55683-37-9 Others Propargyl-PEG-1-acid Propargyl PEG1 acid PropargylPEG1acid Inhibitor inhibitor inhibit