Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 934,000 |
50 mg | 約10-14 週間 | ¥ 1,235,000 |
100 mg | 約10-14 週間 | ¥ 1,744,500 |
説明 | Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM). |
ターゲット&IC50 | ACAT2:0.07 µM |
In vitro | Pyripyropene A inhibits VEGF (20 ng/ml)-induced migration and tubular formation of HUVECs in dose-dependent fashion. Pyripyropene A do not show growth inhibitory effects against KB3-1, K562 and Neuro2A cells.Pyripyropene A exhibits anti-proliferative activity against HUVECs(IC50 value of 1.8 μM)[1]. |
In vivo | Pyripyropene A-treated mice display reduction of atherogenic lesion areas in the aortae and heart. Pyripyropene A inhibits the hepatic e acyl–coenzyme A:cholesterol acyltransferase 2 (ACAT2) activity in vivo[3]. Pyripyropene A displays a half-life (t1/2) of 0.693/λ, where λ represented the terminal slope of the log-linear portion of concentration time profile[4]. |
分子量 | 583.63 |
分子式 | C31H37NO10 |
CAS No. | 147444-03-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Pyripyropene A 147444-03-9 Others Inhibitor inhibitor inhibit