Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 521,000 |
50 mg | 約10-14 週間 | ¥ 684,000 |
100 mg | 約10-14 週間 | ¥ 918,000 |
ターゲット&IC50 | GABA:ki: 34.6 nM , GABA+:36.2 nM (ki) |
In vivo | S-8510 or CGS8216, in combination with PTZ doses exceeding 90 mg/kg, can induce lethal convulsions, specifically enhancing PTZ-induced subconvulsive states. Moreover, scopolamine impairs memory by reducing time spent near a platform, an effect both S-8510 and CGS8216 reverse, thereby mitigating scopolamine-induced amnesia. Additionally, S-8510 counters diazepam-induced memory impairments in both water maze and passive avoidance paradigms and elevates ACh levels up to 100 mg/kg in a dose-dependent manner. It, along with PTZ, also increases extracellular NA levels in the hippocampus. The anxiogenic effects of S-8510, CGS8216, and FG7142 were assessed in Wistar rats using the water lick conflict paradigm. In ddY mice, S-8510 significantly reduces immobility in the forced swimming test at doses ranging from 40 to 80 mg/kg, indicating a dose-dependent improvement in depressive symptoms. For tetrabenazine-induced ptosis, S-8510 effectively lessens ptosis at doses above 10 mg/kg, though at its maximum, it reduces ptosis by only 39%, in contrast to imipramine's more potent reduction of about 80% at 20 mg/kg. |
別名 | SB-737552 phosphate |
分子量 | 340.23 |
分子式 | C12H13N4O6P |
CAS No. | 151466-23-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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S-8510 phosphate 151466-23-8 Others S 8510 phosphate SB-737552 phosphate SB 737552 Phosphate SB-737552 Phosphate S 8510 Phosphate S-8510 Phosphate S8510 phosphate S8510 Phosphate SB737552 Phosphate Inhibitor inhibitor inhibit