store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 18,500 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 57,000 | |||
25 mg | 在庫あり | ¥ 102,000 | |||
50 mg | 在庫あり | ¥ 150,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 52,000 |
説明 | S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM) |
ターゲット&IC50 | MCL1:0.19 nM (Kd) |
In vitro | S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1.?S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway[1]. |
In vivo | In vivo, S63845 shows potent anti-tumour activity with an acceptable safety margin as a single agent in several cancers.?Moreover, MCL1 inhibition, either alone or in combination with other anti-cancer drugs, proved effective against several solid cancer-derived cell lines.?MCL1 as a target for the treatment of a wide range of tumours[1]. |
分子量 | 829.26 |
分子式 | C39H37ClF4N6O6S |
CAS No. | 1799633-27-4 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (40.19 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
S63845 1799633-27-4 Apoptosis BCL S 63845 Inhibitor S-63845 Bcl-2 Family inhibit inhibitor