store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SAR7334 hydrochloride is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
説明 | SAR7334 hydrochloride is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM). |
ターゲット&IC50 | TRPC6 current:7.9 nM |
In vitro | SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells(IC50s of 9.5, 282 and 226?nM)[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1].SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9?nM. SAR7334 (100?nM) substantially reduces TRPC6 currents[3]. |
In vivo | In isolated perfused lungs from mice, SAR7334 (10?mg/kg, p.o.) inhibits TRPC6-dependent acute HPV. it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3]. |
分子量 | 440.79 |
分子式 | C21H24Cl3N3O |
CAS No. | 1333207-63-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (226.87 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SAR7334 hydrochloride 1333207-63-8 Others SAR 7334 Hydrochloride SAR7334 Hydrochloride SAR-7334 Hydrochloride SAR-7334 hydrochloride Inhibitor inhibitor inhibit