Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH 42495 is an orally active neutral metalloendopeptidase inhibitor. SCH 42495 is the orally active ethyl ester prodrug of SCH 42354.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | SCH 42495 is an orally active neutral metalloendopeptidase inhibitor. SCH 42495 is the orally active ethyl ester prodrug of SCH 42354. |
In vitro | SCH 42354 inhibits the hydrolysis of leu-enkephalin and ANF (IC50: 8.3 and 10.0 nM, respectively) [1]. |
In vivo | SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively. SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a significant reduction in pulmonary vascular remodeling and ventricular hypertrophy in hypoxic rats after 10 days. Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) resulting in a decrease in cardiovascular remodeling secondary to chronic hypoxia in rats [1][2]. |
分子量 | 411.58 |
分子式 | C20H29NO4S2 |
CAS No. | 136511-43-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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SCH 42495 136511-43-8 Others SCH42495 SCH-42495 Inhibitor inhibitor inhibit