Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SR-31747 blocks cell proliferation by inhibiting sterol isomerase. SR-31747 is a sigma ligand. It has immunosuppressive and anti-inflammatory properties.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約6-8 週間 | ¥ 68,500 |
25 mg | 約6-8 週間 | ¥ 226,500 |
50 mg | 約6-8 週間 | ¥ 312,500 |
100 mg | 約6-8 週間 | ¥ 427,000 |
1 mL * 10 mM (in DMSO) | 約6-8 週間 | ¥ 69,000 |
説明 | SR-31747 blocks cell proliferation by inhibiting sterol isomerase. SR-31747 is a sigma ligand. It has immunosuppressive and anti-inflammatory properties. |
In vitro | SR-31747 (10 nM) blocks the proliferation of lymphocytes at a concentration. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation [2]. |
In vivo | SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6, and TNF-α in a dose-dependent manner (ED50: 2 mg/kg) in vivo. SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. Ablation of corticosteroids by the use of Mifepristone or adrenalectomy suppresses the effect of SR-31747. Administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxic shock as a result of monokine inhibition [1]. |
分子量 | 396.44 |
分子式 | C23H35Cl2N |
CAS No. | 132173-07-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15.62 mg/mL (39.40 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SR-31747 132173-07-0 Others SR31747 SR 31747 Inhibitor inhibitor inhibit