Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Simvastatin ammonium is an active metabolite of simvastatin lactone mediated. Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約5 days | ¥ 9,000 |
10 mg | 約5 days | ¥ 17,000 |
1 mL * 10 mM (in DMSO) | 約5 days | ¥ 10,500 |
説明 | Simvastatin ammonium is an active metabolite of simvastatin lactone mediated. Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. |
In vitro | The Michaelis-Menten constant (Km) for simvastatin acid uptake by OATP3A1 was 0.017 μM and the Vmax was 0.995 fmol/min/105 cells. There is a pH-dependent effect on organic anion transporting polypeptide 3A1 uptake, with more efficient simvastatin acid uptake at pH5.5 in HEK293 cells transfected with the OATP3A1 gene [1]. |
別名 | Tenivastatin ammonium |
分子量 | 453.62 |
分子式 | C25H43NO6 |
CAS No. | 139893-43-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Simvastatin acid ammonium 139893-43-9 Others Tenivastatin ammonium Inhibitor inhibitor inhibit