Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition. This compound plays a crucial role in the synthesis of a range of PROTACs, including BI-3663, a highly selective PTK2/FAK PROTAC. It employs cereblon ligands to target E3 ligases for the degradation of PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1].
説明 | Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition. This compound plays a crucial role in the synthesis of a range of PROTACs, including BI-3663, a highly selective PTK2/FAK PROTAC. It employs cereblon ligands to target E3 ligases for the degradation of PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1]. |
別名 | Tos-PEG4-Boc |
分子量 | 432.53 |
分子式 | C20H32O8S |
CAS No. | 217817-01-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Tos-PEG4-t-butyl ester 217817-01-1 Others TosPEG4tbutyl ester Tos-PEG-4-t-butyl ester Tos PEG4 t butyl ester Tos-PEG4-Boc Inhibitor inhibitor inhibit