Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 624,500 |
50 mg | 約10-14 週間 | ¥ 822,000 |
100 mg | 約10-14 週間 | ¥ 1,124,500 |
説明 | Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively). |
ターゲット&IC50 | CDK7:2100 nM, Akt3:38 nM, ROCK1:1570 nM, ROCK2:1850 nM, Akt2:328 nM, Akt1:180 nM |
In vitro | Protein targets that bind Uprosertib in the lysate display a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug display no reduction in binding. Uprosertib inhibits Akt1/2/3 (Kd: 16/49/5 nM, respectively) and it also potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts[1]. |
別名 | GSK2141795 (hydrochloride) |
分子量 | 465.71 |
分子式 | C18H17Cl3F2N4O2 |
CAS No. | 1047635-80-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Uprosertib hydrochloride 1047635-80-2 Others GSK 2141795 GSK-2141795 Uprosertib Hydrochloride GSK2141795 GSK2141795 (hydrochloride) Inhibitor inhibitor inhibit