Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VBIT-3 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 31.3 μM). VBIT-3 also is an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | VBIT-3 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 31.3 μM). VBIT-3 also is an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases). |
ターゲット&IC50 | VDAC1:(kd)31.3 μM |
In vitro | VBIT-3 targets the mitochondrial protein VDAC1 and inhibits apoptosis and protect against mitochondria dysfunction. VBIT-3 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis (in HEK-293 cells, IC50s of 8.8±0.56 μM, 6.6±1.03 μM, and 7.5±0.27 μM, respectively). |
分子量 | 453.84 |
分子式 | C21H19ClF3N3O3 |
CAS No. | 2088463-66-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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VBIT-3 2088463-66-3 Others VBIT 3 VBIT3 Inhibitor inhibitor inhibit