Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significantly potentiate the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR).
説明 | Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significantly potentiate the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR). |
植物由来 |
分子量 | 370.445 |
分子式 | C22H26O5 |
CAS No. | 125292-97-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Wallichinine 125292-97-9 Inhibitor inhibitor inhibit