store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Moreover, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. Given its diverse applications, AACOCF3 holds promise for cardiovascular disease research.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約 35 days | ¥ 36,500 |
10 mg | 約 35 days | ¥ 61,500 |
50 mg | 約 35 days | ¥ 248,000 |
説明 | AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Moreover, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. Given its diverse applications, AACOCF3 holds promise for cardiovascular disease research. |
In vitro | AACOCF3 inhibits the release of arachidonic acid from calcium ionophore-challenged U937 cells with IC50 of 8 μM and from platelets with IC50 of 2 μM[1]. AACOCF3 (10 μM) suppresses phosphate-induced calcification and osteogenic/chondrogenic signaling in HAoSMCs. AACOCF3 significantly inhibits both basal and Pi-induced release of arachidonic acid, the product of PLA2 activity[2]. |
In vivo | AACOCF3 (10 mg/kg; gavage; 5 days a week; ApoE–/– mice (6-week-old males) were fed a high-cholesterol diet) significantly reduces type III collagen plaque expression, but had no significant influence on total collagen accumulation[3]. |
別名 | Arachidonyl trifluoromethyl ketone, Arachidonyltrifluoromethane |
分子量 | 356.47 |
分子式 | C21H31F3O |
CAS No. | 149301-79-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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AACOCF3 149301-79-1 Metabolism Phospholipase Arachidonyl trifluoromethyl ketone Arachidonyltrifluoromethane AACOCF 3 AACOCF-3 Inhibitor inhibitor inhibit