Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AChE-IN-21 (Compound I-8) is a highly potent and selective orally active inhibitor of acetylcholinesterase (AChE). It exhibits an impressive inhibitory concentration (IC50) of 2.66 nM. Additionally, AChE-IN-21 demonstrates excellent in vitro blood-brain barrier (BBB) permeability [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | AChE-IN-21 (Compound I-8) is a highly potent and selective orally active inhibitor of acetylcholinesterase (AChE). It exhibits an impressive inhibitory concentration (IC50) of 2.66 nM. Additionally, AChE-IN-21 demonstrates excellent in vitro blood-brain barrier (BBB) permeability [1]. |
In vitro | Compound I-8 (AChE-IN-21) interacts with acetylcholinesterase (AChE) by attaching to both its catalytic active site and peripheral anionic site [1]. |
In vivo | AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.) administered intragastrically once daily for seven consecutive days, significantly mitigates the memory impairment induced by scopolamine in a study involving Kunming mice (male and female, with body weights between 18–22 g, evenly distributed) [1]. The study tested doses of 1.0, 5.0, and 25.0 mg/kg, demonstrating a clear obstruction of the memory deficits caused by scopolamine (2 mg/kg, i.p.) [1]. |
分子量 | 395.49 |
分子式 | C24H29NO4 |
CAS No. | 2413656-04-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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AChE-IN-21 2413656-04-7 Inhibitor inhibitor inhibit