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Adecatumumab (MT201) is a whole-person IgG1 monoclonal antibody to human EpCAM. Adecatumumab has potential anticancer activity and can be used to study breast cancer.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 66,500 |
5 mg | 在庫あり | ¥ 181,000 |
10 mg | 在庫あり | ¥ 282,500 |
25 mg | 在庫あり | ¥ 424,500 |
50 mg | 在庫あり | ¥ 571,500 |
100 mg | 在庫あり | ¥ 771,500 |
説明 | Adecatumumab (MT201) is a whole-person IgG1 monoclonal antibody to human EpCAM. Adecatumumab has potential anticancer activity and can be used to study breast cancer. |
In vitro |
Among human Adecatumumab and murine Adecatumumab, there are diverse kinetic binding activities observed in B16/EpCAM 3E3 cells when treated with Adecatumumab (4 μM; 18 h)[2]. Adecatumumab (0.1 ng/mL-0.1 mg/mL; 4 h) exhibits dose-dependent activity in Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in natural killer (NK) cells[2]. |
In vivo |
In the B16/EpCAM xenograft tumor model in mice, both human adecatumumab and mu-adecatumumab (300 μg/mouse; i.v. bolus injection; 3 times per week) demonstrate inhibition of tumor growth[2]. Both human adecatumumab and mu-adecatumumab (300 μg/mouse; i.v. bolus injection; single dose) display a bi-exponential curve progression of serum concentration, characterized by an early distribution phase between 0 and 10 h and a terminal elimination phase[2]. |
別名 | MT 201 |
分子量 | N/A |
CAS No. | 503605-66-1 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
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Adecatumumab 503605-66-1 Others MT 201 MT201 MT-201 Inhibitor inhibitor inhibit