Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AG 370, an indole tyrphostin, functions as a powerful inhibitor of PDGF-induced mitogenesis, demonstrating an IC50 of 20 μM. Additionally, it exhibits weak inhibition capabilities towards the EGF receptor.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 33,000 |
5 mg | 約 35 days | ¥ 143,000 |
10 mg | 約 35 days | ¥ 250,500 |
25 mg | 約 35 days | ¥ 548,500 |
説明 | AG 370, an indole tyrphostin, functions as a powerful inhibitor of PDGF-induced mitogenesis, demonstrating an IC50 of 20 μM. Additionally, it exhibits weak inhibition capabilities towards the EGF receptor. |
In vitro | AG370 blocks mitogenesis induced by epidermal growth factor (IC50 = 50 microM) and human serum (IC50 = 50 microM). In digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor. [1]. |
分子量 | 259.27 |
分子式 | C15H9N5 |
CAS No. | 134036-53-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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AG-370 134036-53-6 Others AG 370 AG370 Inhibitor inhibitor inhibit