keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alpha-1 antitrypsin (A1AT) is known as a serum trypsin inhibitor and is a protease inhibitor belonging to the serpin superfamily. Alpha-1 antitrypsin is a single-chain glycoprotein consisting of 394 amino acids in the mature form and exhibits a number of glycoforms.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | お問い合わせ | ¥ 11,500 |
5 mg | お問い合わせ | ¥ 33,000 |
10 mg | お問い合わせ | ¥ 54,000 |
25 mg | お問い合わせ | ¥ 75,500 |
説明 | Alpha-1 antitrypsin (A1AT) is known as a serum trypsin inhibitor and is a protease inhibitor belonging to the serpin superfamily. Alpha-1 antitrypsin is a single-chain glycoprotein consisting of 394 amino acids in the mature form and exhibits a number of glycoforms. |
In vitro | A1AT is a major inhibitor of human serine proteases in serum, is produced mainly by the liver, but also by extrahepatic cells, including neutrophils and certain cancer cells. AAT is an acute-phase protein and its concentration rises up to 3–4-fold above normal during acute inflammation. Several types of cancer, including non-small cell lung adenocarcinoma, have been associated with increased serum levels of AAT [1][2][3]. |
In vivo | Moreover, not only the native, the inhibitory form of AAT but also conformationally modified, non-inhibitory forms are suggested to play a role in modulating tumor growth and invasiveness. For example, Kataoka and co-workers have shown that the C-terminal fragment of AAT can enhance the growth and invasiveness of human pancreas adenocarcinoma cells, in vivo [5]. |
分子量 | 1804.01 |
分子式 | C79H130N22O26 |
CAS No. | TP2217 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: > 45.1 mg/mL, Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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alpha-1 antitrypsin fragment TP2217 Others alpha 1 antitrypsin fragment a-1 antitrypsin fragment α-1 antitrypsin fragment alpha1 antitrypsin fragment Inhibitor inhibitor inhibit