keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Angiopep-2 hydrochloride is a brain-targeting peptide vector. Conjugating anticancer agents to Angiopep-2 may enhance their therapeutic effect against brain cancer [1].
説明 | Angiopep-2 hydrochloride is a brain-targeting peptide vector. Conjugating anticancer agents to Angiopep-2 may enhance their therapeutic effect against brain cancer [1]. |
In vitro | Paclitaxel is conjugated with the brain peptide carrier Angiopep-2 hydrochloride, forming a compound called ANG1005. This paclitaxel-Angiopep-2 hydrochloride conjugate, ANG1005, enters the brain to a greater extent and circumvents P-glycoprotein (P-gp) more effectively. ANG1005 exhibits antitumor activity against human cancer cell lines comparable to that of paclitaxel [1]. |
In vivo | Administration of ANG1005 significantly enhances the survival rates of mice with intracranial implantation of U87 MG glioblastoma or NCI-H460 lung cancer cells [1]. |
分子量 | 2337.93 |
分子式 | C104H150ClN29O31 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Angiopep-2 hydrochloride Inhibitor inhibitor inhibit