keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Angiotensin 1-7 (Ang-(1-7)) acetate, an endogenous heptapeptide from the renin-angiotensin system (RAS), exhibits cardioprotective effects through its anti-inflammatory and anti-fibrotic activities in cardiac cells. It effectively inhibits purified canine ACE activity (IC 50 =0.65 μM) and serves as a local synergistic modulator of kinin-induced vasodilation by hindering ACE and facilitating nitric oxide release. Additionally, this compound prevents Ang II-induced proliferation and hypertrophy in smooth muscle cells, alongside demonstrating antiangiogenic and growth-inhibitory effects on the endothelium [1] [2] [3].
説明 | Angiotensin 1-7 (Ang-(1-7)) acetate, an endogenous heptapeptide from the renin-angiotensin system (RAS), exhibits cardioprotective effects through its anti-inflammatory and anti-fibrotic activities in cardiac cells. It effectively inhibits purified canine ACE activity (IC 50 =0.65 μM) and serves as a local synergistic modulator of kinin-induced vasodilation by hindering ACE and facilitating nitric oxide release. Additionally, this compound prevents Ang II-induced proliferation and hypertrophy in smooth muscle cells, alongside demonstrating antiangiogenic and growth-inhibitory effects on the endothelium [1] [2] [3]. |
In vitro | Angiotensin 1-7 (Ang-(1-7)) exhibits opposing roles to angiotensin II by inhibiting growth in cultured vascular smooth muscle cells, contrasting with angiotensin II's growth-stimulating effect at equal molar concentrations[2]. It also counteracts the myofibroblast phenotype induced by methylglyoxal-modified albumin (MGA) in NRK-52E cells by mitigating the prolonged activation of the TGF-β-ERK pathway[4]. Moreover, Angiotensin 1-7 operates through the Mas receptor (MasR), diverging from the angiotensin II/angiotensin II type 1 receptor (AT1R) pathway, which facilitates anti-inflammatory, vasodilatory, and neuroprotective actions[5]. |
In vivo | Daily administration of Angiotensin 1-7 (Ang-(1-7)) at doses ranging from 0.01 to 0.06 mg/kg significantly alleviates Di-nitrochlorobenzene (DSS)-induced colitis. This treatment notably decreases the colitis-associated phosphorylation of p38, ERK1/2, and Akt[3]. |
分子量 | 959.06 |
分子式 | C43H66N12O13 |
CAS No. | 2855063-75-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 125 mg/mL (130.34 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Angiotensin (1-7) (acetate) 2855063-75-9 Angiotensin (17) (acetate) Angiotensin (1 7) (acetate) Angiotensin Inhibitor inhibitor inhibit