Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound SC9, an anti-inflammatory agent, serves as a potent and selective inhibitor of the Drp1-Fis1 interaction, mitigating FIS1-mediated mitochondrial dysfunction. It exhibits an in vitro IC50 value of 270 nM for inhibiting GTPase activity [1].
説明 | Compound SC9, an anti-inflammatory agent, serves as a potent and selective inhibitor of the Drp1-Fis1 interaction, mitigating FIS1-mediated mitochondrial dysfunction. It exhibits an in vitro IC50 value of 270 nM for inhibiting GTPase activity [1]. |
In vitro | The compound acts as an anti-inflammatory agent (49), diminishing (LPS)-induced mitochondrial dysfunction in H9c2 cells, and rescues mice from (LPS)-induced endotoxemia. |
In vivo | Anti-inflammatory agent 49 (10 mg/kg, every 8 hours for 72 hours) can treat endotoxemia induced by LPS in mice [1]. |
分子量 | 466.52 |
分子式 | C21H22N8O3S |
CAS No. | 851471-44-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Anti-inflammatory agent 49 851471-44-8 Inhibitor inhibitor inhibit