Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antioxidant agent-3 (Compound 14q), a potent antioxidant, exhibits strong scavenging activity against DPPH radicals and ABTS+ radicals, with IC50 values of 26.58 μM and 30.31 μM, respectively. Additionally, it enhances the levels of reactive oxygen species (ROS), superoxide dismutase (SOD), and glutathione (GSH), while diminishing lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | Antioxidant agent-3 (Compound 14q), a potent antioxidant, exhibits strong scavenging activity against DPPH radicals and ABTS+ radicals, with IC50 values of 26.58 μM and 30.31 μM, respectively. Additionally, it enhances the levels of reactive oxygen species (ROS), superoxide dismutase (SOD), and glutathione (GSH), while diminishing lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells [1]. |
In vitro | Antioxidant agent-3 (Compound 14q) demonstrates significant efficacy in scavenging DPPH and ABTS+ radicals, with IC50 values of 26.58 μM and 30.31 μM, respectively. It exhibits low cytotoxicity towards human WI-38 (IC 50 > 100 μM) and GES (IC 50 > 200 μM) cells, indicating a favorable safety profile. Furthermore, Antioxidant agent-3 enhances the viability and reduces apoptosis in H2O2-damaged HepG2 cells by decreasing reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release while improving glutathione (GSH) and superoxide dismutase (SOD) levels. These effects, coupled with its increased stability in methanol solution, underscore its potential as a therapeutic antioxidant. The conducted assays, including cytotoxicity in WI-38 and GES cell lines and viability in H2O2-injured WI-38 and HepG2 cells, support these findings by demonstrating reduced toxicity, enhanced cell viability, and protection against apoptosis and cellular damage. |
分子量 | 358.3 |
分子式 | C18H14O8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Antioxidant agent-3 Inhibitor inhibitor inhibit