Powder: -20°C for 3 years | In solvent: -80°C for 1 year
APC-6860 is a trypsin-like serine proteases inhibitor with k i values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k i values of 0.1, 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer.
説明 | APC-6860 is a trypsin-like serine proteases inhibitor with k i values of 0.21, 0.44, 1.5, 16.8, 20, 30 μM for uPA, trypsin, tryptase, tPA, thrombin and factor Xa, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k i values of 0.1, 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer. |
ターゲット&IC50 | Thrombin:20 μM (Ki), Urokinases (murine):0.082 μM (Ki), FXa:30 μM (Ki), Urokinases (human):0.1 μM (Ki), uPA:0.21 μM (Ki), Tryptase:1.5 μM (Ki), Trypsin:0.44 μM (Ki), TPA:16.8 μM (Ki) |
In vitro | APC-6860 (compounds 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC 50 s of 1.4 and 3.1 μM, respectively[2]. |
分子量 | 302.13 |
分子式 | C9H7IN2S |
CAS No. | 154628-42-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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APC-6860 154628-42-9 APC 6860 APC6860 Inhibitor inhibitor inhibit