Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ARN5187 is a lysosomal compound, REV-ERB β Ligand. ARN5187 inhibits REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 shows lysosomal efficacy and cytotoxicity, and can induce apoptosis.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | ARN5187 is a lysosomal compound, REV-ERB β Ligand. ARN5187 inhibits REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 shows lysosomal efficacy and cytotoxicity, and can induce apoptosis. |
In vitro | ARN5187 (compound 1) (0-100 μM; 48 h) shows cytotoxicity with EC 50 of 23.5 μM in BT-474 cells and IC 50 of 30.14 μM, >100 μM for BT-474 and HMEC cells, respectively [1] [2]. ARN5187 (0-100 μM) activates the RevRE reporter in a concentration-dependent manner in HEK-293 cells [1]. ARN5187 (25, 50 μM) is a lysosomotropic-independent REV-ERB antagonistic activity [1]. ARN5187 (50 μM; 24 h) shows autophagy inhibition [1]. ARN5187 (50 μM; 2, 8, 24 h) effects autophagy formation and maturation [1]. Cell Cytotoxicity Assay [1] Cell Line: BT-474 cells Concentration: 0-100 μM Incubation Time: 48 h Result: Showed cytotoxicity with EC 50 of 23.5 μM. RT-PCR [1] Cell Line: BT-474 cells Concentration: 25, 50 μM Incubation Time: Result: Significantly enhanced the expression of BMAL1, PER1 and PEPCK in a dose-dependent manner. Western Blot Analysis [1] Cell Line: BT-474 cells Concentration: 50 μM Incubation Time: 24 h Result: Significantly increased the expression of α-LC3-II, α-p62, α-Cleaved PARP. |
分子量 | 397.53 |
分子式 | C24H32FN3O |
CAS No. | 1287451-26-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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ARN5187 1287451-26-6 Inhibitor inhibitor inhibit