Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATIC-IN-1 (compound 14) acetate is an ATIC dimerization inhibitor with a K i value of 685 nM, essential for AICAR transformylase activity. It demonstrates anti-tumor effects by decreasing cell proliferation and division rates [1].
説明 | ATIC-IN-1 (compound 14) acetate is an ATIC dimerization inhibitor with a K i value of 685 nM, essential for AICAR transformylase activity. It demonstrates anti-tumor effects by decreasing cell proliferation and division rates [1]. |
In vitro | ATIC-IN-1 acetate at concentrations of 10 µM and 50 µM is a specific inhibitor that exhibits non-specific aggregation mechanisms whether in the presence or absence of bovine serum albumin (BSA) at 1 mg/mL and 10 mg/mL [1]. At higher concentrations ranging from 100-500 µM over 48 hours, ATIC-IN-1 acetate inhibits the proliferation of MCF-7 cells [1]. Additionally, at 250 µM over a period of 24 to 72 hours, it leads to a reduction in cell division rather than an increase in cell death [1]. |
分子量 | 523.58 |
分子式 | C23H37N7O7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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ATIC-IN-1 acetate Others Inhibitor inhibitor inhibit