Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC 50 of 7.3. BCAT-IN-1 is 100-fold more selective for BCATm than BCATc ( pIC 50 =5.4). BCAT-IN-1 can be used for the research of metabolic diseases [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 54,000 |
25 mg | 約6-8 週間 | ¥ 351,500 |
50 mg | 約6-8 週間 | ¥ 457,000 |
100 mg | 約6-8 週間 | ¥ 684,000 |
説明 | BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC 50 of 7.3. BCAT-IN-1 is 100-fold more selective for BCATm than BCATc ( pIC 50 =5.4). BCAT-IN-1 can be used for the research of metabolic diseases [1]. |
In vitro | BCAT-IN-1 (compound 8b) inhibits BCATm in human cells, with a pIC 50 of 7.0 [1]. BCAT-IN-1 inhibits mouse BCATm in the cellular assay with pIC 50 of 5.9 [1]. |
In vivo | BCAT-IN-1 (compound 8b), administered orally at doses ranging from 30 to 300 mg/kg, elevates c BCAA levels in an acute mouse model for an extended period [1]. At a lower dose of 5 mg/kg via oral route, BCAT-IN-1 demonstrates an oral bioavailability (F=28%) and a peak concentration (C max) of 1648 ng/mL in mice [1]. When given intravenously at 1 mg/kg, it shows a half-life (t 1/2 =9.2 hours) and a clearance rate (Cl=4.0 mL/min/kg) in mice [1]. |
分子量 | 538.46 |
分子式 | C25H24BrN5O2S |
CAS No. | 2581243-32-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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BCAT-IN-1 2581243-32-3 BCATIN1 BCAT IN 1 Inhibitor inhibitor inhibit