Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL. It displays an IC50 value of 0.034 nM, suggesting its strong inhibitory activity specifically against Bcl-2. Additionally, Bcl-2-IN-2 exhibits an IC50 value of 43 nM against Bcl-xL, demonstrating over 1000-fold selectivity for Bcl-2 compared to Bcl-xL.
説明 | Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL. It displays an IC50 value of 0.034 nM, suggesting its strong inhibitory activity specifically against Bcl-2. Additionally, Bcl-2-IN-2 exhibits an IC50 value of 43 nM against Bcl-xL, demonstrating over 1000-fold selectivity for Bcl-2 compared to Bcl-xL. |
ターゲット&IC50 | BCL-XL:43 nM (IC50), BCL2:0.034 nM (IC50) |
In vitro | Bcl-2-IN-2 effectively targets and inhibits the Bcl-2-G101V mutant at a concentration of 1.2 nM and demonstrates potent inhibition of RS4;11 cell proliferation with an IC50 value of 1.9 nM[1]. |
分子量 | 876.09 |
分子式 | C48H57N7O7S |
CAS No. | 2383085-86-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Bcl-2-IN-2 2383085-86-5 Bcl2IN2 Bcl 2 IN 2 Inhibitor inhibitor inhibit