Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.
説明 | Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2. |
分子量 | 669.56 |
分子式 | C33H34Cl2N4O7 |
CAS No. | 119673-08-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
DMSO: Soluble
You can also refer to dose conversion for different animals. 詳細
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Becatecarin 119673-08-4 Inhibitor inhibitor inhibit