Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2. It exhibits antiproliferative activity [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2. It exhibits antiproliferative activity [1]. |
ターゲット&IC50 | BRD4 BD1:0.64 nM, BRD4 BD2:0.25 nM |
In vitro | BET-IN-15 (Compound 1) demonstrated antiproliferative activity over 72 hours, with IC50 values of 3.14 nM and 1.56 nM against MV4-11 and Kasumi-1 cells, respectively [1]. |
In vivo | Compound 1 (BET-IN-15), upon 72-hour exposure, exhibits antiproliferative activity with IC50s of 3.14 nM and 1.56 nM against MV4-11 and Kasumi-1 cells, respectively [1]. |
分子量 | 444.45 |
分子式 | C21H18F2N4O3S |
CAS No. | 2408994-22-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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BET-IN-15 2408994-22-7 Chromatin/Epigenetic Epigenetic Reader Domain Inhibitor inhibitor inhibit