Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 μM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 20,500 |
5 mg | 約 35 days | ¥ 82,500 |
10 mg | 約 35 days | ¥ 154,500 |
説明 | Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 μM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step. |
分子量 | 291.71 |
分子式 | C13H11ClFN5 |
CAS No. | 220088-42-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform: Slightly soluble
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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Binucleine 2 220088-42-6 Inhibitor inhibitor inhibit