Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family. It inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. Additionally, BN82002 hydrochloride exhibits approximately 20-fold greater selectivity over CD45 tyrosine phosphatase.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 12,000 |
5 mg | 約5 days | ¥ 22,500 |
1 mL * 10 mM (in DMSO) | 約5 days | ¥ 22,500 |
説明 | BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family. It inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. Additionally, BN82002 hydrochloride exhibits approximately 20-fold greater selectivity over CD45 tyrosine phosphatase. |
ターゲット&IC50 | CDC25B2:3.9 μM (IC50), CDC25A:2.4 μM (IC50), CDC25B3:6.3 μM (IC50), CDC25C:5.4 μM (IC50), CDC25C-cat:4.6 μM (IC50) |
In vitro | The in vitro impact of BN82002 on the proliferation of various human tumor cell lines was assessed, employing Menadione, a known proliferation inhibitor, as a benchmark. BN82002 and Menadione were observed to inhibit proliferation across all tested cell lines in a concentration-dependent fashion within the low micromolar range. Particularly, the pancreatic cancer cell line MIA PaCa-2 demonstrated the highest sensitivity to BN82002 with an IC 50 of 7.2 μM, while the colon cancer cell line HT-29 exhibited the least sensitivity with an IC 50 of 32.6 μM. This sensitivity pattern closely mirrors that seen with Menadione (5-15 μM). Additionally, it was found that a 50 μM concentration of BN82002 effectively halted cell proliferation. However, this arrest saw only a slight shift in the cell cycle, characterized by a minor decrease in the S phase and a rise in cells at both G1 and G2 DNA content stages, indicating BN82002-induced arrest occurs at various cell cycle phases[1]. |
分子量 | 395.88 |
分子式 | C19H26ClN3O4 |
CAS No. | 1049740-43-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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BN82002 hydrochloride 1049740-43-3 BN-82002 hydrochloride BN 82002 Hydrochloride BN82002 Hydrochloride BN-82002 Hydrochloride Inhibitor inhibitor inhibit