keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA), is a 22 amino acid fragment of CNP and functions as an agonist for the natriuretic peptide receptor B (NPR-B). It can inhibit cAMP synthesis, which is induced by histamine, 5-HT, or Forskolin. Additionally, CNP exhibits strong endothelial-derived relaxation properties and acts as a growth inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |
---|---|---|---|
1 mg | お問い合わせ | ¥ 29,000 | |
5 mg | お問い合わせ | ¥ 114,500 | |
10 mg | お問い合わせ | お問い合わせ | |
50 mg | お問い合わせ | お問い合わせ |
説明 | C-Type Natriuretic Peptide (CNP) (1-22), human (TFA), is a 22 amino acid fragment of CNP and functions as an agonist for the natriuretic peptide receptor B (NPR-B). It can inhibit cAMP synthesis, which is induced by histamine, 5-HT, or Forskolin. Additionally, CNP exhibits strong endothelial-derived relaxation properties and acts as a growth inhibitor. |
In vitro | C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) (0.01, 0.1, 1, 10, 100, 1000 nM) increases cGMP production in CHO cells expressing human NPR-B in a concentration-dependent manner[1]. PK parameters of CNP immunoreactivity after a single intravenous administration of C-Type Natriuretic Peptide (CNP) (1-22), human (TFA)[1]: Dose (nM/kg) AUC 0→∞ (pM?min/mL) MRT 0→∞ (min) T 1/2 (min) CL tot (mL/min/kg) Vd ss (mL/kg) 20 320±54 1.02±0.18 1.42±0.45 63.9±11.9 64.2±5.1 PK parameters of CNP immunoreactivity after a single subcutaneous administration of C-Type Natriuretic Peptide (CNP) (1-22), human (TFA)[1]: Dose (nM/kg) Cmax (pM/mL) Tmax (min) AUC 0→∞ (pM?min/mL) MRT 0→∞ (min) T 1/2 (min) BA (%) 50 9.02±3.74 5.0±0.0 152±73 13.9±3.4 10.0±5.0 19±9 Each value represents the mean±SD of 3 rats. MRT=mean residence time, CL tot =total clearance, T 1/2 =half-life period, BA=bioavailability. i.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide[3]. |
分子量 | 2311.64 |
分子式 | C95H158F3N27O30S3 |
CAS No. | 1966153-17-2 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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C-Type Natriuretic Peptide (CNP) (1-22), human TFA 1966153-17-2 CType Natriuretic Peptide (CNP) (122), human TFA C-Type Natriuretic Peptide (CNP) , human TFA C Type Natriuretic Peptide (CNP) (1 22), human TFA Inhibitor inhibitor inhibit