Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 18,000 |
5 mg | 約 35 days | ¥ 81,000 |
10 mg | 約 35 days | ¥ 136,500 |
25 mg | 約 35 days | ¥ 312,500 |
説明 | C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease. |
別名 | C2-8 |
分子量 | 510.2 |
分子式 | C19H14Br2N2O3S |
CAS No. | 300670-16-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 33 mg/mL
DMSO: 33 mg/mL
DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
You can also refer to dose conversion for different animals. 詳細
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C2-8 300670-16-0 C2 8 C28 C-2-8 Inhibitor inhibitor inhibit