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Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab has anti-inflammatory activity, inhibiting inflammation associated with autoimmune diseases by neutralizing IL-1β signaling. Canakinumab has anti-inflammatory activity, inhibiting inflammation associated with autoimmune diseases by neutralizing IL-1β signaling.Canakinumab has been used for the treatment of gout and coronary artery disease.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 108,500 |
2 mg | 在庫あり | ¥ 152,000 |
5 mg | 在庫あり | ¥ 228,000 |
10 mg | 在庫あり | ¥ 305,500 |
25 mg | 在庫あり | ¥ 454,500 |
50 mg | 在庫あり | ¥ 615,000 |
100 mg | 在庫あり | ¥ 831,000 |
説明 | Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab has anti-inflammatory activity, inhibiting inflammation associated with autoimmune diseases by neutralizing IL-1β signaling. Canakinumab has anti-inflammatory activity, inhibiting inflammation associated with autoimmune diseases by neutralizing IL-1β signaling.Canakinumab has been used for the treatment of gout and coronary artery disease. |
ターゲット&IC50 | IL-1β:43.6 pM (human), IL-1β:40.8 pM (marmoset) |
In vitro | Dose-dependently, Canakinumab (0-7 nM) represses IL-6 production in marmoset peripheral blood mononuclear cells, demonstrating IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively[2]. Effectively, Canakinumab competes with IL-1RI and IL-1RII for binding to IL-1b[2]. |
別名 | ACZ 885, Ilaris |
分子量 | N/A |
CAS No. | 914613-48-2 |
store at low temperature
store at -20°C
You can also refer to dose conversion for different animals. 詳細
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Canakinumab 914613-48-2 Immunology/Inflammation IL Receptor ACZ 885 Ilaris Inhibitor inhibitor inhibit