Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 μM. CAY10760 (20 μM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib .
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 210,500 |
50 mg | 約6-8 週間 | ¥ 273,500 |
100 mg | 約6-8 週間 | ¥ 434,000 |
説明 | CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 μM. CAY10760 (20 μM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib . |
分子量 | 485.96 |
分子式 | C28H24ClN3O3 |
CAS No. | 391889-85-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 11 mg/mL
DMF:PBS (pH 7.2) (1:2): 0.3 mg/mL
DMSO: 10 mg/mL
You can also refer to dose conversion for different animals. 詳細
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CAY10760 391889-85-3 CAY 10760 CAY-10760 Inhibitor inhibitor inhibit