Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 22,000 |
50 mg | 約6-8 週間 | ¥ 181,000 |
100 mg | 約6-8 週間 | ¥ 271,000 |
説明 | CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1]. |
ターゲット&IC50 | CDK5:8.8 nM (IC50), CDK2:6.0 nM (IC50) |
In vitro | CDK5 inhibitor 20-223 (10 nM-10 μM; 72 hours) potently inhibits cell growth in a panel of colorectal cancer (CRC) cell lines[1].CDK5 inhibitor 20-223 (0.3125-20 μM; 6 hours) induces a dose-dependent decrease in pRB (S807/811) and pFAK (S732) levels in each of the three CRC cell lines[1]. Cell Viability Assay[1] Cell Line: CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells |
In vivo | CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) shows anti-tumor activity in human CRC xenograft tumors in nude mice[1]. Animal Model: Athymic nude mice[1] |
別名 | CDK5 inhibitor 20-223 |
分子量 | 305.37 |
分子式 | C19H19N3O |
CAS No. | 865317-30-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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CDK5 inhibitor 20-223 865317-30-2 CDK5 inhibitor 20223 CDK5 inhibitor 20 223 CDK-5 inhibitor 20-223 Inhibitor inhibitor inhibit