Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 521,000 |
50 mg | 約10-14 週間 | ¥ 684,000 |
100 mg | 約10-14 週間 | ¥ 918,000 |
説明 | Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1]. |
In vitro | Chk1-IN-5 (compound 3; concentrations of 0.4, 1.2, 3.7, 11.1, 33.3, and 100 nM) effectively blocks Chk1 phosphorylation in HT-29 colon cells[1]. |
In vivo | Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells[1].Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) displays a longer half-life (T1/2=3.8 hours) and higher exposure (CL=2.3 L/hr?kg; Vss=6.4 L/kg; AUC=4531 ng/ml?h)[1]. Animal Model: Baib/c nude mice with HT-29 colon cancer cells[1] |
別名 | Chk1-IN-5 |
分子量 | 383.38 |
分子式 | C18H18FN7O2 |
CAS No. | 2120398-39-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Chk1-IN-5 2120398-39-0 Chk-1-IN-5 Chk1IN5 Chk1 IN 5 Inhibitor inhibitor inhibit