Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically active BV-2 cells with an IC50 value of 2.5 μM. Additionally, CIAC001 demonstrates anti-neuroinflammation effects in mouse models and attenuates chronic morphine-induced addiction [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 349,000 |
50 mg | 約8-10 週間 | ¥ 454,500 |
100 mg | 約8-10 週間 | ¥ 574,000 |
説明 | CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically active BV-2 cells with an IC50 value of 2.5 μM. Additionally, CIAC001 demonstrates anti-neuroinflammation effects in mouse models and attenuates chronic morphine-induced addiction [1]. |
In vitro | CIAC001 (10 μM; 6 hours) inhibits LPS-induced (200 ng/mL) morphological changes in microglia in BV-2 cells [1]. |
In vivo | CIAC001 administered intraperitoneally at doses of 20 µg/kg and 0.2 mg/kg, once daily for seven days, dose-dependently mitigated naloxone-induced withdrawal jumping in morphine-dependent mice and significantly inhibited the development of behavior sensitization induced by morphine during the induction phase [1]. Additionally, CIAC001 at a dose of 20 mg/kg, given intraperitoneally once daily for seven days, did not notably impair memory or cognitive function in the Y maze test in mice [1]. |
分子量 | 339.43 |
分子式 | C20H25N3O2 |
CAS No. | 2649154-82-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CIAC001 2649154-82-3 Inhibitor inhibitor inhibit