Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows promise for the investigation of inflammatory diseases [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows promise for the investigation of inflammatory diseases [1]. |
In vivo | Compound 5b (COX-2/5-LOX-IN-3), when administered orally to male Sprague Dawley rats, demonstrates significant in vivo anti-inflammatory effects. Specifically, at a dosage of 2.622 x 10^-5 mol/kg, compound 5b achieved a 58.77% inhibition of edema four hours post-administration, highlighting its potent anti-inflammatory activity within this animal model. |
分子量 | 361.85 |
分子式 | C17H16ClN3O2S |
CAS No. | 2481484-51-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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COX-2/5-LOX-IN-3 2481484-51-7 Inhibitor inhibitor inhibit