Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 44,000 |
5 mg | 在庫あり | ¥ 108,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 120,000 |
説明 | CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits human CTPS1 and human CTPS2, and can be used in studies of arthritis and rheumatoid arthritis. |
ターゲット&IC50 | CTPS1(human):32 nM, CTPS2 (human):18 nM |
In vivo | In the Mouse collagen-induced arthritis (CIA) model, CTP Synthetase-IN-1 (10 mg/kg, p.o; twice daily; for 18 days) exhibited significant pharmacological responses[1]. |
分子量 | 512.53 |
分子式 | C20H19F3N6O3S2 |
CAS No. | 2338811-71-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (156.09 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CTP Synthetase-IN-1 2338811-71-3 Others Inhibitor inhibitor inhibit