Powder: -20°C for 3 years | In solvent: -80°C for 1 year
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約 35 days | ¥ 33,000 |
10 mg | 約 35 days | ¥ 55,000 |
25 mg | 約 35 days | ¥ 119,500 |
50 mg | 約 35 days | ¥ 220,500 |
説明 | The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation. |
分子量 | 276.13 |
分子式 | C13H10BrNO |
CAS No. | 337932-29-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16 mg/mL
Ethanol: 1 mg/mL
DMF: 25 mg/mL
DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Cuspin-1 337932-29-3 Cuspin 1 Cuspin1 Inhibitor inhibitor inhibit