Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CYP1B1-IN-3 is a potent, selective inhibitor of CYP1B1, exhibiting IC50 values of 6.6 nM for CYP1B1, 347.3 nM for CYP1A1, and >10000 nM for CYP1A2. It also impedes cell migration and invasion, and inhibits the P-gp, AKT/ERK, FAK/SRC, and EMT pathways [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | CYP1B1-IN-3 is a potent, selective inhibitor of CYP1B1, exhibiting IC50 values of 6.6 nM for CYP1B1, 347.3 nM for CYP1A1, and >10000 nM for CYP1A2. It also impedes cell migration and invasion, and inhibits the P-gp, AKT/ERK, FAK/SRC, and EMT pathways [1]. |
ターゲット&IC50 | CYP1B1:6.6 nM, CYP1A1:347.3 nM, CYP1A2:>10000 nM |
In vitro | CYP1B1-IN-3 (compound 77) at concentrations of 3.75-30.0 μM over 72 hours enhances the sensitivity of A549/Taxol cells to Taxol (0.06-1 μM) [1]. Additionally, at concentrations of 2.5, 5, and 10 μM, CYP1B1-IN-3 inhibits migration and invasion in both A549 and A549/Taxol cells [1]. Furthermore, CYP1B1-IN-3 at the same concentrations for 24 hours suppresses the AKT/ERK, FAK/SRC, and EMT pathways in A549/Taxol cells [1]. |
分子量 | 413.49 |
分子式 | C20H16FN3O2S2 |
CAS No. | 2872575-51-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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CYP1B1-IN-3 2872575-51-2 Inhibitor inhibitor inhibit