Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1] [2].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1] [2]. |
In vitro | Methylation analysis reveals a [3H]DHAC LD 10 exposure leads to 25.06% DNA hypomethylation in L1210/0 cells and 46.32% in L1210/dCK(-) deoxycytidine kinase mutant cells relative to controls [2]. Furthermore, dihydro-5-azacytidine (DHAC) vies with cytidine triphosphate for RNA integration, culminating in ribosomal breakdown and impaired protein synthesis [1]. |
In vivo | In a murine model bearing L1210/0-induced tumors, administration of an LD 10 of Dihydro-5-azacytidine (DHAC; 1500 mg/kg) results in a peak plasma concentration of 317 μM. The compound is biexponentially eliminated, with a first-phase half-life (t 1/2 α) of 1.03 hours and a second-phase half-life (t 1/2 β) of 5 hours [2]. |
別名 | DHAC acetate, NSC 264880 acetate |
分子量 | 306.27 |
分子式 | C10H18N4O7 |
CAS No. | 2470972-18-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Dihydro-5-azacytidine acetate 2470972-18-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Nucleoside Antimetabolite/Analog DHAC acetate NSC 264880 acetate Inhibitor inhibitor inhibit