store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elamipretide acetate (MTP 131 acetate) is a derivative of Elamipretide, a small mitochondria-targeting tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that can be used in studies to reduce the production of toxic reactive oxygen species and stabilize cardiolipin.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | お問い合わせ | ¥ 13,500 |
5 mg | お問い合わせ | ¥ 29,000 |
10 mg | お問い合わせ | ¥ 44,500 |
25 mg | お問い合わせ | ¥ 86,000 |
50 mg | お問い合わせ | ¥ 114,000 |
100 mg | お問い合わせ | ¥ 175,000 |
説明 | Elamipretide acetate (MTP 131 acetate) is a derivative of Elamipretide, a small mitochondria-targeting tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that can be used in studies to reduce the production of toxic reactive oxygen species and stabilize cardiolipin. |
In vitro |
In vitro experiment it exhibited that treatment with 1 µM elamipretide in cultured ARPE-19 cells results in accelerating an increase in mitochondrial volume.[3] In vitro, added in the freeze media with 1 and 10 µM Elamipretide obviously improved post-thaw sperm parameters including motility and viability, stability of the plasma membrane, and mitochondria and chromosomes.[4] In control INS1 cells, treatment with 1 µM Elamipretide for 20 h suffiently increase the engulfment of mitochondria into autophagosomes, but it has no increase at 10 µM Elamipretide, suggesting a complete reversal of mitochondrial fragmentation induced by nutrient excess at 10 µM, while not being complete at 1 µM.[5] |
In vivo |
In vivo, 1 mg/kg MTP-131 treatment reversed visual decline without improving glycemic control or reducing body weight in diabetic mouse models.[6] In vivo test it shown that treatment repeatedly with 5 mg/kg elamipretide intraperitoneally in mice provided maximum neuroprotective effects without any adverse effects[7]. Treatment with 3 mg/kg/day SS-31 (elamipretide) restored redox homeostasis, improved mitochondrial quality, and increased exercise tolerance without an increase in mitochondrial content in aged mice.[8] |
別名 | MTP 131 acetate, Elamipretide acetate (736992-21-5 Free base) |
分子量 | 699.84 |
分子式 | C34H53N9O7 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Elamipretide acetate 736992-21-5 Free base MTP 131 Acetate MTP 131 acetate Elamipretide Acetate MTP131 Acetate 736992-21-5 MTP-131 Acetate Elamipretide acetate (736992-21-5 Free base) Inhibitor inhibitor inhibit