Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 substrates, including the non-cholestatic estrogen metabolite, estradiol 3-(β-D-glucuronide) .2,3E217G has also been reported to be transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2 (a breast cancer resistance protein transporter), and the rat organic anion-transporting polypeptides 1-4.2
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約 35 days | ¥ 42,000 |
10 mg | 約 35 days | ¥ 79,500 |
25 mg | 約 35 days | ¥ 145,500 |
50 mg | 約 35 days | ¥ 227,500 |
説明 | Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 substrates, including the non-cholestatic estrogen metabolite, estradiol 3-(β-D-glucuronide) .2,3E217G has also been reported to be transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2 (a breast cancer resistance protein transporter), and the rat organic anion-transporting polypeptides 1-4.2 |
分子量 | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
DMF: 10 mg/mL
DMSO: 20 mg/mL
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate) Estradiol 17-(β-D-Glucuronide) Estradiol 17-(b-D-Glucuronide) Estradiol 17-(beta-D-Glucuronide) sodium Hydrate Estradiol 17 (β D Glucuronide) (sodium salt hydrate) Estradiol 17(βDGlucuronide) (sodium salt hydrate) Inhibitor inhibitor inhibit