Powder: -20°C for 3 years | In solvent: -80°C for 1 year
F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarction. Furthermore, F 15845 finds utility in the investigation of myocardial functional impairment [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 491,500 |
50 mg | 約6-8 週間 | ¥ 639,500 |
100 mg | 約6-8 週間 | ¥ 808,000 |
説明 | F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarction. Furthermore, F 15845 finds utility in the investigation of myocardial functional impairment [1]. |
In vitro | F 15845, at concentrations ranging from 10 nM to 10 μM, has been shown to concentration-dependently mitigate veratrine-induced diastolic contracture in isolated atria, with an IC50 value of 0.14 μM [1]. Additionally, when administered at 0.1 to 10 μM, it effectively preserves the viability of isolated cardiomyocytes challenged with lysophosphatidylcholine (LPC) [1]. At a specific concentration of 0.3 μM, F 15845 significantly counteracts the increase in sodium levels ([Na+]) observed during no-flow ischemia, and when applied at the same concentration over a duration of 0-35 minutes, it not only delays the reduction in [Na+] but also prominently marks and sustains it upon reperfusion [1]. |
In vivo | F 15845, administered intravenously at doses of 5 mg/kg, demonstrates significant cardioprotective effects in anesthetized rats. This includes a substantial reduction in infarct size, a decrease in troponin I levels, and the prevention of long-term infarct size expansion, underscoring its potential therapeutic benefits in cardiac injury models. |
分子量 | 375.55 |
分子式 | C20H25NO2S2 |
CAS No. | 470454-73-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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F15845 470454-73-0 Inhibitor inhibitor inhibit